HATU is used for synthesis of Nα-urethane protected β-amino alcohols and peptide alcohols. The aspartate epimerization can be controlled during the coupling of caspase specific tetrapeptides with aromatic amines by HATU as a coupling reagent and 2,4,6-tri-tert-butyl-pyridine (TBP) as additive. Also used in rapid automated derivatization of solid-phase supports for oligonucleotide synthesis.
