HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate, is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid.
SKU: 148893-10-1
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HATU is used for synthesis of Nα-urethane protected β-amino alcohols and peptide alcohols. The aspartate epimerization can be controlled during the coupling of caspase specific tetrapeptides with aromatic amines by HATU as a coupling reagent and 2,4,6-tri-tert-butyl-pyridine (TBP) as additive. Also used in rapid automated derivatization of solid-phase supports for oligonucleotide synthesis.

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Attribute nameAttribute value
CAS NO148893-10-1
Synonyms1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium, 3-oxide hexafluorophosphate, coupling reagent, peptide coupling, amide bond
Molecular Weight380.235
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